Design and Construction of Hybrid Microcapsules with Higher-Order Structure and Multiple Functions.

Guangyu Wu,Xin Huang,Lei Wang,Ping Wen,Chao Ma,Yudong Huang,Pei Zhou

doi:10.1002/advs.201700460

Guangyu Wu, Xin Huang + Show 5 more

Open Access

https://doi.org/10.1002/advs.201700460

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Abstract

The construction of inorganic‐protein hybrid microcapsules by using bovine serum albumin, metal ion clusters, and poly (N‐isopropylacrylamide) nanoconjugates as building blocks is presented. These microcapsules have robust membranes, which can keep their spherical morphology. They support interfacial catalytic activity by the ion clusters on their surface, and can be used as a platform to immobilize enzyme on the interface of oil/water to increase the diversity and efficiency of catalysis. These microcapsules also act as a container to make materials away from bacteria when existing silver clusters on the membrane. The obtained results highlight the construction of these microcompartments. These novel microcompartments can provide some new opportunities in bottom‐up synthetic biology, bioinspired microstorage/ microreactor, and drug/gene delivery in the future.

Highlights

The construction of inorganic-protein hybrid microcapsules by using bovine building blocks, the generated proteinoserum albumin, metal ion clusters, and poly (N-isopropylacrylamide) nanosomes show a promising application conjugates as building blocks is presented
By mixing the BSA–AuNC25 with PNIPAAm (Mn = 30 000 g mol−1, monomer repeat units = 259; Figures S4–S6, Supporting Information), the hybrid building block BSA– AuNC25–PNIPAAm was obtained by the covalent binding between the trithiol group and the AuNCs
Using Rhodamine B isothiocyanate-labeled BSA (RITC-BSA) as the control, the fluorescence signal preserves much more for the dots than RITC-BSA upon prolonged continuous excitation (Figures S9 and S10, Supporting Information), indicating outstanding photostability of the BSA–AuNC25–PNIPAAm

Summary

Introduction

The construction of inorganic-protein hybrid microcapsules by using bovine building blocks, the generated proteinoserum albumin, metal ion clusters, and poly (N-isopropylacrylamide) nanosomes show a promising application conjugates as building blocks is presented. The incorporation of the AuNCs or AgNCs into the membrane allowed the constructed HPs to show additional virtues compared with that of without metal ion hybrid capsules, including photoluminescence, self-rehydration, enhanced antibacterial effect, and enhanced interfacial catalysis (Scheme 1).

Results

Conclusion