Design and construction of an 8-channel transceiver coil array for rat imaging at 9.4 T

Abstract

Ultra-high field (UHF) small animal magnetic resonance imaging (MRI) is a crucial tool permitting investigation of metabolic diseases and identification of imaging biomarkers suitable for clinical diagnosis and translation. Radiofrequency (RF) coils are critical components in enabling acquisition of high-quality rat abdomen MRI data. However, efficient RF coils with high-channel count, capable of sensitive and accelerated rat abdomen imaging at 9.4 T, are not available commercially. The SNR of the commonly-used 9.4 T birdcage coil is relatively weak, particularly in the peripheral area of the subject. In addition, the birdcage is not readily to perform parallel imaging due to unavailability of the required multiple channels. Consequently, the extended scanning duration may cause unnecessary hazards to the rat. In this work, an 8-channel transceiver coil array was designed and constructed to provide good image quality and large coverage for rat abdomen imaging at 9.4 T. The structure and the performance of the developed array was optimized and evaluated by numerical electromagnetic simulations and bench tests, respectively. The MR imaging experiments in phantoms and rat models were also performed on a Bruker 9.4 T preclinical MRI system to validate the feasibility of the proposed design. The coil array supports a one-dimensional acceleration factor up to R = 4, providing good parallel imaging capabilities. These results demonstrated that the proposed 8-channel transceiver coil array for rat imaging has the ability to obtain high spatial resolution of rat abdomen anatomical structure images at 9.4 T.