Abstract
This article illustrates the Design and Characterization of Mucoadhesive microspheres with Famotidine Hydrochloride as drug for Gastro-Retention of drug release. The microspheres were prepared by the Ion Gelation method and Thermal Cross Linking Method. In Ion Gelation method sodium alginate is used as a release controlling biopolymer and Calcium chloride is acts as hygroscopic cross linking agent. In Thermal Cross Linking Method egg albumin is used as binding agent and a Thermal energy is used as cross linking property. The characteristics like shape and structure of prepared microspheres by Optical microscopy and scanning electron microscopy, respectively. In vitro drug release studies were done and drug release was evaluated. Effect on the Mucoadhesion, drug Entrapment Efficiency of microspheres and Drug release were observed. The prepared microspheres exhibited prolonged drug release (17 hrs) the mean particle size increased as the concentration of sodium alginate increased, as the egg albumin concentration increases the Mucoadhesion increased and the drug release rate decreased at higher concentration of sodium alginate. Significant effect of the Encapsulation Efficiency of microspheres was observed. In vitro studies demonstrated the Gastro retentive delivery of drug from the microspheres.
Highlights
Famotidine is a competitive histamine H2-receptor antagonist
Medicines which might be effectively absorbed from gastrointestinal tract (GIT) and have quick half of-lives are eliminated rapidly from the systemic circulation
Mucoadhesive microspheres of Famotidine Hydrochloride was prepared by thermal cross linking method. 0.4% of Tweens 80 was added to 100mL of light liquid paraffin and it was heated to 70°C till tweens 80 was completely dissolved
Summary
Famotidine is a competitive histamine H2-receptor antagonist. Their principal pharmacodynamics outcome is the inhibition of gastric secretion. Famotidine binds competitively to H2-receptors located on the basolateral membrane of the parietal cell, blocking histamine influences This competitive inhibition outcome in lowered basal and nocturnal gastric acid secretion and reduction in gastric quantity, acidity. Medicines which might be effectively absorbed from gastrointestinal tract (GIT) and have quick half of-lives are eliminated rapidly from the systemic circulation Common dosing of those medications is required to attain suitable therapeutic activity. To avoid this quandary, the progress of oral sustained-controlled liberate formulations is an attempt to release the drug slowly into the gastrointestinal tract (GIT) and preserve an effective drug awareness within the systemic circulation for a very long time. Gastro retentive drug supply is a process to extend gastric time, thereby focusing on site-precise drug unlock in the higher gastrointestinal tract (GIT) for nearby or systemic results [1-10]
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