Abstract
Magnetic tissue scaffolds are a promising powerful tool for performing interstitial tumor hyperthermia against the residual bone cancer cells, after surgical intervention. The design of the implant architecture is crucial for several biomedical requirements. However, to date, the influence of implant topology on the hyperthermia treatment outcome has never been assessed. Furthermore, the heating ability is a function of sample mass and geometry. In this work, a simple methodology for designing biomimetic scaffolds using triply periodic minimal surfaces is presented. A set of geometries is 3D printed by fused deposition modeling, using a commercial poly-lactic acid filament filled with magnetite particles, never tested for biomedical applications. Magnetic scaffolds were thoroughly characterized by performing static magnetic measurements, differential scanning calorimetric and thermogravimetric analysis, but, mostly, by carrying out calorimetric measurements to determine their hyperthermic potential under different experimental conditions. Numerical multiphysics simulations with a commercial finite element software were performed, resulting in good agreement with the measurements. The scaffolds were exposed to a magnetic field with 15 mT strength, working at 400 kHz, in air, and the surface temperature was recorder using infrared camera. The manufactured magnetic scaffolds can increase the temperature above 41°C (about 54-57°C), in 40–60 s. In distilled water, for a 30 mT magnetic field and 400 kHz, the temperature was recorded using an optic fiber and we observed that all the sample could be used as thermo-seed for cancer therapy. Finally, the scaffolds were tested in agarose phantoms and their hyperthermic potential was quantified.
Highlights
AGNETO-responsive biomaterials are multifunctional devices which can be synthesized by chemical doping of bioceramics with ferrous ions [1]-[3] or by loading polymers with micro- or nanoparticles [4]-[6] (Fig. 1)
Given the extensive characterization of Triply Periodic Minimal Surfaces (TPMS) magnetic scaffolds, we developed a numerical framework for simulating the multiphysics phenomena related to the calorimetric measurements
A promising solution is the use of properly designed multifunctional magnetic biomaterials as prosthetic implant to be used after tumor resection for i) favoring the bone repair and healing and ii) performing, on demand, by the remote application of an external radiofrequency magnetic field, the hyperthermia treatment for eliminating the potential residual cancer cells, favoring other therapeutic modalities
Summary
AGNETO-responsive biomaterials are multifunctional devices which can be synthesized by chemical doping of bioceramics with ferrous ions [1]-[3] or by loading polymers with micro- or nanoparticles [4]-[6] (Fig. 1). With the same magnetic scaffold is possible to non-invasively monitor the tissue growth by using magnetic resonance imaging (MRI), quantifying the changes in the relaxation times of the nanocomposite implant [16]-[18]. This class of third generation biomaterials, if exposed to a radiofrequency field, dissipate noticeable heat, which can be used to trigger the drug release of chemotherapeutics [1], [6]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
