Abstract
Core-shell nanofibers with the ability to carry multiple drugs are attracting the attention to develop appropriate drug delivery systems for wounds dressing applications. In this study, biocompatible core-shell nanofibers have been designed as a promising dual-drug carrier with the capability of delivering both water-soluble and organic solvent-soluble drugs simultaneously. With the aim of fabricating the core-shell nanofibers, the dipping method has been employed. For this propose, core nanofibers made from polyvinyl alcohol (PVA) were immersed in various concentrations of polyacrylonitrile (PAN) and cross-linked by dipping into ethanol. Diclofenac sodium salt (DSs) and gentamicin sulfate (GENs) have been loaded into the core and shell nanofibers as models of the drug, respectively. The morphology study of core-shell nanofibers showed that the concentrations between 1% w/w up to 2% w/w PAN/GENs, with deep penetration into the internal layers of PAV/DSs nanofibers could lead to the core-shell structure. The cytotoxicity results showed the competency of designed core-shell nanofibers for wound dressing application. Also, the release profile exhibits the controllable behavior of drug release.
Highlights
Nanofibers with simulating the extracellular matrix (ECM)[1,2], are showing the appropriate potential for design the wound dressing and drug delivery systems[3]
It was observed that polyvinyl alcohol (PVA)/Diclofenac sodium salt (DSs) with a concentration of 5 mg/mL qualified without any bead and compared with similar structures where bead formation has been explained[23]
The scanning electron microscopy (SEM) images showed that the morphology of PVA/DSs nanofibers affected by 0.5% w/w of PAN/ gentamicin sulfate (GENs) solution due to the high concentration of dimethylformamide (DMF)
Summary
While the distribution and penetration of PAN/GENs polymer related to the concentrations less than 2% w/w into the PVA/DSs nanofibers caused to increase the intensity in comparison to the high concentrations of PAN/GENs. The results showed that core-shell nanofibers formed with the maximum yield by using the concentrations from 0.5% w/w to 2% w/w. Decreasing the thermal stability could be related to morphology change of core-shell nanofiber with 0.5% w/w PAN/GENs concentration as showed in SEM results (Fig. 2(c)). The results showed that part of the drug was released during the washing process, but the core-shell nanofibers with concentrations of 1% to 2% PAN showed relevant results use as a carrier for drugs and current structure meet the demands to be used as local drug delivery systems for wound dressing
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