Design and characterization of delavirdine ethosomal drug delivery to enhance the bioavailability via topical drug delivery

Abstract

The increasing demand for efficient administration and delivery of pharmaceutical dosage forms possessing the attributes namely minimum side effects, improved patient compliance has resulted in the formulation of novel drug delivery system. Ethosomes are very effective since they enhance the penetration of drugs via skin to several times whose compound to the simple creams, elixirs and liposomal carriers. Hence, there is an absolute necessity to formulate ethosomes of the selected drugs, In the presant work ethosomal formulations of, delaviridine, was prepared for obtaining the objective of improving skin permeability and bioavailability. The prepared formulations gave good percentage yield and size distribution. The best formulation of ethosomes of each respected drug were incorporated into carbopol based gel systems for controlled release and the invitro studies proven that the formulations followed zero order release mechanisms. Compatability studies were performed for the materials selected and results are observed o be possitive. Stability studies indicated that the formulations were stable at low temperatures but can undergo rapid deformation at higher temperatures.