Abstract
A discrete insulin infusion based on long-time interval measurement is the classic technique for diabetes treatment. Nevertheless, in this research, a closed-loop control system was proposed for continuous drug infusion to overcome the drawbacks of these typical discrete methods and develop more practical diabetes therapy systems. A blood glucose-insulin system was implemented relying on continuous insulin injection model. Based on this model, two controllers were designed to deal with the control dilemma of the resulting highly nonlinear plant. The controllers designed in this paper are: proportional integral derivative (PID), and sliding table controllers. Simulation results have shown that the sliding table controller can outperform the PID controller even with severe circumstances of disturbance in glucose, such as exercise, delay or noise in glucose sensor and nutrition mixed meal absorption at meal times.
Highlights
Many researchers have attempted to find methods for diagnosing and treating diabetes disease
The controllers designed in this paper are: proportional integral derivative (PID), and sliding table controllers
Simulation results have shown that the sliding table controller can outperform the PID controller even with severe circumstances of disturbance in glucose, such as exercise, delay or noise in glucose sensor and nutrition mixed meal absorption at meal times
Summary
Many researchers have attempted to find methods for diagnosing and treating diabetes disease. A fully automated closed-loop insulin delivery system ( known as an artificial pancreas) could potentially be the ultimate answer for blood glucose control in diabetic patients This system can mimic the activity of a normal pancreas and is capable of maintaining physiological blood glucose levels for insulindependent diabetic patients. The artificial pancreas is a system of integrated devices containing only synthetic materials, which substitutes for a pancreas by sensing plasma glucose concentration, calculating the amount of insulin needed, and delivering the correct amount of insulin Such a device is comprised of a glucose monitoring sensor, an insulin pump, and a control algorithm to regulate the pump to deliver the insulin in order to maintain the normality of glycemia in presence of sensor measurements
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