Abstract
In this paper, we introduce a novel type of transdermal drug delivery device (TD3) with a micro-electro-mechanical system (MEMS) design using computer-aided design (CAD) techniques as well as computational fluid dynamics (CFD) simulations regarding the fluid interaction inside the device during the actuation process. For the actuation principles of the chamber and microvalve, both thermopneumatic and piezoelectric principles are employed respectively, originating that the design perfectly integrates those principles through two different components, such as a micropump with integrated microvalves and a microneedle array. The TD3 has shown to be capable of delivering a volumetric flow of 2.92 × 10−5 cm3/s with a 6.6 Hz membrane stroke frequency. The device only needs 116 Pa to complete the suction process and 2560 Pa to complete the discharge process. A 38-microneedle array with 450 µm in length fulfills the function of permeating skin, allowing that the fluid reaches the desired destination and avoiding any possible pain during the insertion.
Highlights
The usage of transdermal drug delivery devices (TD3 ) based on micro-electro-mechanical systems (MEMS) and NEMS technology is increasing [1,2,3]
The transdermal drug delivery (TDD) method refers to medicine administration through the skin at determined depths [3,4,5]
We present the TD3 design device using computer-aided design (CAD)
Summary
The usage of transdermal drug delivery devices (TD3 ) based on micro-electro-mechanical systems (MEMS) and NEMS technology is increasing [1,2,3]. The transdermal drug delivery (TDD) method refers to medicine administration through the skin at determined depths [3,4,5] These new devices are facing some challenges, such as the drugs dose effectiveness and the pain caused during the dosing process by the insertion devices. Due to the forces generated underunder the increased pressure in the heated a membrane membrane causes changeand of volume and the lower∆V chamber, and ΔP, expands andexpands causes aand change of avolume pressure inpressure the lowerinchamber, and ∆P,ΔV respectively These valves are Valves are strategically positioned to avoid unwanted reversed flows.reversed. Research from the Department of Mechanical and Materials Engineering, Queen’s University from Canada, reported the development of a PZT actuator based on poly(dimethylsiloxane) (PDMS), with a peak flow rate of 135 μL/min and a maximum back pressure of 25 mm H2 O at an actuation frequency of. The suction and discharge are the micropumps basic movements, which will be the main design parameters to take into account during the structural allocation
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