Abstract
Ventilator-induced lung injury aggravates the existing lung injury. This study investigated the effect of desflurane on VILI in a rat model of acute respiratory distress syndrome. Forty-eight rats were randomized into a sham (S) group, control (C) group, lipopolysaccharide/ventilation (LV) group, lipopolysaccharide/ventilation/desflurane (LVD) group, or lipopolysaccharide/low ventilation with and without desflurane (LLV and LLVD) groups. Rats in the S group received anesthesia only. Rats in the LV and LVD groups received lipopolysaccharide and were ventilated with a high tidal volume. Rats in LLV and LLVD groups were treated as the LV and LVD groups and ventilated with a low tidal volume. PaO2/FiO2, lung wet-to-dry weight ratios, concentrations of inflammatory factors in serum and BALF, histopathologic analysis of lung tissue, and levels of nuclear factor- (NF-) κB protein in lung tissue were investigated. PaO2/FiO2 was significantly increased by desflurane. Total cell count, macrophages, and neutrophils in BALF and proinflammatory factors in BALF and serum were significantly decreased by desflurane, while IL-10 was increased. The histopathological changes and levels of NF-κB protein in lung tissue were decreased by desflurane. The results indicated that desflurane ameliorated VILI in a rat model of acute respiratory distress syndrome.
Highlights
Mechanical ventilation is an essential part of life support in the intensive care unit, but it can lead to ventilatorinduced lung injury (VILI) [1, 2]
Evidence suggests that the nuclear factor- (NF-)κB-mediated inflammatory response plays a pivotal role in the development of acute respiratory distress syndrome (ARDS) and VILI [7, 8]
The results show that desflurane ameliorated VILI in a rat model of ARDS
Summary
Mechanical ventilation is an essential part of life support in the intensive care unit, but it can lead to ventilatorinduced lung injury (VILI) [1, 2]. Some reports suggest that desflurane induces airway constriction, increases lung microvascular permeability, and aggravates lung injury [16,17,18], and data describing the contribution of desflurane to VILI in patients with ARDS are scarce. To address these disparate findings, the present study was performed to test the effect of desflurane on VILI in an ARDS model and investigate whether desflurane is suitable for use in patients with lung dysfunction. BioMed Research International anesthesia in mechanically ventilated patients with prior lung injury
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