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Abstract
After chronic exposure to neurokinin A, a time-dependent and recoverable desensitization of inositol monophosphate accumulation occurred in B82 fibroblasts transfected with cDNAs encoding for the bovine stomach NK 2 receptor. Desensitized cells also showed decreased Ca 2+ mobilization. While NK 2 receptor antagonists had no effect on inositol monophosphate accumulation, substance P and senktide both produced a small degree of desensitization.
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Schedule a callMore From: European Journal of Pharmacology: Molecular Pharmacology
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