Abstract
The immunotherapeutic effects of the methanol extraction residue (MER) of BCG were investigated in strain 2 guinea pigs injected with cells of the transplantable, diethylnitrosamine-induced, line 10 hepatocarcinoma. MER was more effective in mediating tumour regression in guinea pigs obtained from the Weizmann Institute of Science, Rehovot, Israel than in animals obtained from the National Institutes of Health. Repeated skin testing with solubilized tumour antigen of MER-treated animals whose tumours had regressed led to recurrent tumour growth and/or susceptibility to rechallenge in six of nine guinea pigs so treated. These results suggest the existence of minimal residual disease even in animals which respond positively to immunotherapy.
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