Abstract

BackgroundThere are approximately 35,000 human deaths from rabies in Asia annually. Rabies can be prevented through timely post-exposure prophylaxis (PEP) consisting of wound washing, rabies vaccine, and in some cases, rabies immunoglobulin (RIG). However, access to rabies PEP often remains limited to urban areas and is cost-prohibitive. There is little information on procurement, distribution, monitoring, and reporting of rabies PEP. MethodsWe interviewed key informants in the public sector from various levels in Bangladesh, Bhutan, Cambodia, and Sri Lanka between March 2017 and May 2018 using a descriptive assessment tool to obtain information on procurement, distribution, monitoring, and reporting of rabies PEP. These four countries in Asia were chosen to showcase a range of rabies PEP systems. National rabies focal points were interviewed in each country and focal points helped identify additional key informants at lower levels. ResultsA total of 22 key informants were interviewed at various levels (central level to health facility level) including national rabies focal points in each country. Each country has a unique system for managing rabies PEP procurement, distribution, monitoring, and reporting. There are varying levels of PEP access for those with potential rabies exposures. Rabies PEP is available in select health facilities throughout the country in Bangladesh, Bhutan, and Sri Lanka. In Cambodia, rabies PEP is limited to two urban centers. The availability of RIG in all four countries is limited. In these four countries, most aspects of the rabies PEP distribution system operate independently of systems for other vaccines. However, in Bhutan, rabies PEP and Expanded Programme on Immunization (EPI) vaccines share cold chain space in some locations at the lowest level. All countries have a monitoring system in place, but there is limited reporting of data, particularly to the central level. ConclusionSystems to procure, deliver, monitor, and report on rabies PEP are variable across countries. Sharing information on practices more widely among countries can help programs to increase access to this life-saving treatment.

Highlights

  • Rabies is caused by a lyssavirus and is nearly 100% fatal once clinical symptoms occur

  • Rabies post-exposure prophylaxis (PEP) consists of wound washing, immediate rabies vaccination following the potential exposure, and in some cases, rabies immunoglobulin (RIG)

  • We interviewed key informants to obtain information on procurement, distribution, monitoring, and reporting of rabies PEP, using a descriptive assessment tool

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Summary

Introduction

Rabies is caused by a lyssavirus and is nearly 100% fatal once clinical symptoms occur. Rabies causes an estimated 59,000 human deaths annually with approximately 60% of cases occurring in Asia [1]. Rabies in humans can be prevented through timely and appropriate post-exposure prophylaxis (PEP). Rabies PEP consists of wound washing, immediate rabies vaccination following the potential exposure, and in some cases, rabies immunoglobulin (RIG). Only cell-culture or embryonated egg-based rabies vaccines (CCEEVs) are recommended by the World Health Organization (WHO); the original nerve-tissue based vaccine (NTBV) has not been recommended since the 1980s [3,4]. There are approximately 35,000 human deaths from rabies in Asia annually. Rabies can be prevented through timely post-exposure prophylaxis (PEP) consisting of wound washing, rabies vaccine, and in some cases, rabies immunoglobulin (RIG). There is little information on procurement, distribution, monitoring, and reporting of rabies PEP

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