Abstract
The aim of the study was to determine the titer of antibodies against gram-negative bacterial endotoxins in diseases of various microbial etiology in children, to assess its diagnostic value and to evaluate the immunological properties of antiendotoxic immunity. It was found that the percentage of seropositive sera to GShPB antigens was convincingly higher in children with MEK and IID than in healthy children. The percentage of detection of antitoxin antibodies depended on the type of microorganism. The most important in YID were Escherichia coli i Pseudomonas aeruginosa, and in MEK were Escherichia coli. In terms of the intensity of antitoxin antibody formation, MEK differed sharply from other groups. While “medium” and “high” titers were detected mainly in the CEC, only “low” titers were detected in healthy and YID-observed children. Determination of the intensity of antibody formation against GShPB endotoxins at "medium" and "high" titers is recommended as an additional diagnostic and prognostic criterion in the diagnosis of MEC.
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