Descemet Stripping Endothelial Keratoplasty

Abstract

To determine the outcomes and complication rates achieved by a novice cornea surgeon when performing Descemet stripping automated endothelial keratoplasty (DSAEK) while precisely following a previously described forceps insertion technique. Prospective, noncomparative interventional case series including 100 eyes of 74 patients with endothelial decompensation. An institutional review board approved, prospective, DSAEK series was initiated. Cases included all initial patients with endothelial failure operated on by a single surgeon after his cornea fellowship training. The surgeon strictly adhered to a previously published 5-mm incision, folded forceps graft insertion technique. Patients were followed at 1 day, 1 week, and 1, 3, and 6 months. Postoperative complications (including graft dislocation, primary graft failure, and pupillary block), best spectacle-corrected visual acuity (BSCVA) and specular microscopy of central endothelial cell density at 6 months postoperatively were the main outcome measures. One hundred consecutive eyes were enrolled in the study, and 100% follow-up at 6 months was achieved. Postoperative complications included 2 graft dislocations (2%), and both grafts were attached successfully and cleared; 2 episodes of cystoid macular edema (2%) occurred, and 1 eye (1%) developed areas of anterior iris synechiae to the graft. There were no pupillary block episodes or primary graft failures. In eyes without comorbidity (n=57), the mean BSCVA improved from 20/48 preoperation to 20/29 at 6 months after operation (P<0.001). No eyes lost vision. Mean central endothelial cell density decreased from 2769 cells per square millimeter preoperatively to 2308 cells per square millimeter postoperatively at 6 months. This represented a mean cell loss of 16%. This study demonstrates that with meticulous attention to a standardized forceps insertion technique, excellent outcomes with low rates of complications, improved BSCVA, and low endothelial cell loss can be achieved with DSAEK surgery.