Abstract
In this experiment we investigated in rats the effectsof chronic injections (13×1.0 μg and 13×2 μg i.m.) and one actue injection (0.3 μg s.c.) of des-Tyr-γ-endorphin (DTdγE) on the pineal content of melatonin and arginine vasopressin (AVP). Compared with control level all three regimens of DTγE significantly elevated pineal melatoni. The greatest increase was obtained with the 0.3 μg acute dose while the smallest increase was obtained with the 2 μg chronic dose. In contrast to the effect on melatonin, pooled levels of pineal AVP were lower DTγE treated rats than in control rats. The greatest reduction was obtained with the 2 μg chronic dose and the smallest reduction was obtained with the 1 μg chronic dose.
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