Abstract
Cudrania tricuspidata (C. tricuspidata) is widespread throughout East Asia and in China and Korea, and it is widely used as a traditional remedy against eczema, mumps, and tuberculosis. With regard to the aforementioned medical efficacy, various studies are continuously being conducted, and it has been reported that C. tricuspidata extract has various actions against inflammation, diabetes, obesity, and tumors. Therefore, we evaluated antiplatelet effects using derrone in C. tricuspidata. We examined the effect of derrone on the phosphorylation of vasodilator-stimulated phosphoprotein (VASP) and inositol 1, 4, 5-triphosphate receptor I (IP3RI), and on the dephosphorylation of cytosolic phospholipase A2 (cPLA2), mitogen-activated protein kinases p38 (p38MAPK), and Akt, which affects platelet function and thrombus formation. Various agonists-induced human platelets were inhibited by derrone without cytotoxicity, and it also decreased the intracellular calcium level through the signaling molecule phosphorylations. In addition, derrone inhibited glycoprotein IIb/IIIa (αIIb/β3) affinity. Thus, in the present study, derrone suppressed human platelet aggregation and thrombin-induced clot formation.
Highlights
In normal circulation of blood, platelets are necessary for hemostasis and thrombosis. [1]. e cardiovascular diseases (CVDs) are becoming a critical threat to our lives in these years
It is widely accepted that platelets play an important role in cardiovascular disease as they have a fundamental role in thrombosis. erefore, many drugs or natural substances have been developed to treat CVDs. [2, 3]
Regarding the effects of Cudrania tricuspidata (C. tricuspidata) extracts for improving blood circulation, Evidence-Based Complementary and Alternative Medicine research has reported that the C. tricuspidata extract has antiplatelet effects on rat platelet aggregation [15]. erefore, in this study, we evaluate the potential efficacy of derrone from unripe fruits of C. tricuspidata
Summary
In normal circulation of blood, platelets are necessary for hemostasis and thrombosis. [1]. e cardiovascular diseases (CVDs) are becoming a critical threat to our lives in these years. E cardiovascular diseases (CVDs) are becoming a critical threat to our lives in these years. It is widely accepted that platelets play an important role in cardiovascular disease as they have a fundamental role in thrombosis. Erefore, many drugs or natural substances have been developed to treat CVDs. There is an ever-increasing interest toward different traditional medicines (mainly, herbal remedies) in different diseases, including CVDs [5,6,7]. Various ginsenosides have been used as a traditional herbal medicine against several diseases, especially CVDs [8]. Reviewing these options could enable scientists to examine and introduce novel efficacious medicines
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