Abstract
Dementia and stroke are common disorders in the elderly that have great impact on brain functioning and the way people live their lives. Magnetic Resonance Imaging (MRI) of the brain has proven to be an important tool for etiologic research on these neurological diseases. The Rotterdam Scan Study is a large-scale prospective population-based brain imaging study that aims to investigate causes and consequences of age-related brain changes. The Rotterdam Scan Study was initiated as part of the ongoing Rotterdam Study. In 1995 and 1999 random subsets of the Rotterdam Study underwent MRI of the brain, whereas from 2005 onwards MRI has been implemented into the core protocol of the Rotterdam Study. In this paper, we discuss the background of this study and summarize the main findings to date. Finally, plans for future research within the Rotterdam Scan Study are described.
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