Abstract
Dermaseptins are a group of α-helical shaped polycationic peptides isolated from the Hylid frogs, with antimicrobial effects against bacteria, parasites, protozoa, viruses in vitro. Besides, anti-tumor effects have been demonstrated. However, few animal experiments and no clinical trials have been conducted thus far. This review summarizes the current knowledge on the pharmacology, ethno pharmacology, effectivity against infectious pathogens and tumors cells and the mechanism of action of the Dermaseptins. Future research should focus on further clarification of the mechanisms of action, the effectivity of Dermaseptins against several cancer cell lines and their applicability in humans.
Highlights
Dermaseptins (DRSs) are a family of peptides that are part of the skin secretions of several Hylid frogs, from the Agalychnis and Phyllomedusa family (Nicolas and Amiche, 2006; Amiche et al, 2008)
DRSs are often classified as antimicrobial peptides (AMPs), since they show effectivity in vitro against some gram positive and gram negative bacteria, parasites, yeasts, protozoa, viruses and display immune modulatory effects (Mor et al, 1994a; Mor et al, 1994b; Strahilevitz et al, 1994; Charpentier et al, 1998; Brand et al, 2002; Navon-Venezia et al, 2002; Brand et al, 2006; Conceicao et al, 2006; Conlon et al, 2007; Leite et al, 2008; Galanth et al, 2009; Nicolas and El Amri, 2009; Jiang et al, 2014; Zairi et al, 2014; Huang et al, 2017)
The aim of this review is to summarize the current knowledge on DRSs, to elaborate on the ethnopharmacology, the potential therapeutic values with respect to their anti-microbial and antitumor potency, and to suggest future directions for research
Summary
Dermaseptins (DRSs) are a family of peptides that are part of the skin secretions of several Hylid frogs, from the Agalychnis and Phyllomedusa family (Nicolas and Amiche, 2006; Amiche et al, 2008). DRSs are often classified as antimicrobial peptides (AMPs), since they show effectivity in vitro against some gram positive and gram negative bacteria, parasites, yeasts, protozoa, viruses and display immune modulatory effects (Mor et al, 1994a; Mor et al, 1994b; Strahilevitz et al, 1994; Charpentier et al, 1998; Brand et al, 2002; Navon-Venezia et al, 2002; Brand et al, 2006; Conceicao et al, 2006; Conlon et al, 2007; Leite et al, 2008; Galanth et al, 2009; Nicolas and El Amri, 2009; Jiang et al, 2014; Zairi et al, 2014; Huang et al, 2017). We thereby restricted ourselves to DRSs (sensu stricto) according to the nomenclature proposed by Amiche et al (2008)
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