Abstract
Although preterm birth is the delivery before 37 + 0 weeks of gestation, the majority of prema-turity-related complications occur before 33 + 0 weeks of gestation. The need of today is to select the best agent out of the broad spectrum of available tocolytic agents, for providing maximum benefit to unfortunate sufferers of prematurity. The study aims to assess the role of “Dermal Nitroglycerin Patch” in treatment of preterm labour. Method: Study conducted in Department of Obstetrics & Gynecology, NIMS Medical College & Hospital, Jaipur from July 2014-December 2014. A prospective randomized study of 50 women of preterm labor was enrolled after informed consent. Patients were given dermal nitroglycerin patch as tocolytic agent according to study protocol. Result: 1) Results of NTG PATCH are comparable with other tocolytic drugs in terms of successful tocolysis; 2) Maternal and fetal outcome is favourable in cases of NTG PATCH USE in preterm labour; 3) Side effect profile was also better with NTG Patch. Conclusion: This randomized prospective study lends support to the proportion that Transdermal Nitroglycerine (NTG Patch) may be promising safe, effective, well tolerated, cost effective and non invasive method of tocolysis.
Highlights
In the era of modern obstetrics, where there has been a rapid advancement in all specialties including obstetrical practice, even today the preterm labor still remains an enigma for the obstetrician
Association is being noted between patient with history of preterm labour pain and the same patient presented with preterm labour pain at the same or earlier gestational age in present pregnancy (Table 3). 12 (24%) patients had history of preterm labour pain in previous pregnancy
None of the currently available tocolytic agents are ideal. This in depth study, on the basis of its findings concludes that: 1) Results of NTG PATCH are comparable with other tocolytic drugs in terms of successful tocolysis
Summary
In the era of modern obstetrics, where there has been a rapid advancement in all specialties including obstetrical practice, even today the preterm labor still remains an enigma for the obstetrician. The incidence of preterm birth ranges from 10% - 15% of all deliveries in India whereas in developed countries it lies between 5% - 10% [1]. The therapeutic foundation for treating preterm labour involves the use of tocolysis. It is well proved that when prolongation of pregnancy is not hazardous either to mother or to fetus, the best place for im-. The initial goal of tocolytic therapy is prolongation of pregnancy even for a short period of time to have advantage of steroid therapy as well as the NICU care [2]. Preterm birth is defined as delivery before 37 + 0 weeks of gestation, the majority of prematurity-related adverse outcomes relate to birth before 33 + 0 weeks of gestation
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