Dermal integration of hyaluronic acid fllers: observation in real clinical practice

Abstract

A clinical observation of the dermal integration of low-concentration products based on hyaluronic acid produced by KPM and IPN-Like technologies is presented. KPM technology is a method of obtaining a cohesive poly-compacted gel matrix of hyaluronic acid, which determines the peculiarity of distribution in the skin due to particles of different densities in one product. On the one hand, the drug remains at the injection site after injection due to dense particles, on the other hand, translocation of loose particles into a more modifed part of the dermis. The clinical effect is manifested in the form of full integration of the drug into the dermis, imitating natural volumes. IPN-Like technology involves the preparation of a hyaluronic acid preparation from two monophase chains with low and high elasticity. Interpenetrating stabilized chains are obtained under pressure. Partial independence of IPN structures is necessary for the predicted integration and distribution of the drug in tissues, whereas the increased density of cross-linking nodes strengthens the intensity of the chemical bond, strengthens the fxation of the drug at the injection site. The study was conducted on seven patients using ultrasound scanning before the procedure, during the procedure to control the introduction into the required layer, 15 minutes after the procedure and 2 months later. To objectify the data, skin proflometry was used and photodocumentation in the designated time frame. In the presented clinical case, when comparing the distribution of fllers based on hyaluronic acid, it was revealed that all drugs are well distributed in the surface layers of the dermis, which makes it possible to safely inject drugs created using IPN-Like technology in the same techniques and to the same depth as the drug with CPM technology. According to ultrasound of the skin, drugs produced by IPN-Like technology showed greater effectiveness in terms of dermis thickness after 2 months.