Derived and enhanced compound action potentials at near-threshold levels: Forward masking increases sensitivity of audiograms and tuning curves

Abstract

The amplitude of a cochlear nerve compound action potential (CAP) can be increased by forward maskers having levels close to the visual detection threshold of the CAP. This effect, termed enhancement, varies as a function of the frequency of the masker and probe stimulus, and is nonmonotonic with respect to the level of the masker. Other studies using the derived CAP have used a subtraction technique to evaluate the ability of simultaneous maskers having levels near the CAP visual detection threshold to influence the CAP produced by an above threshold tone. The present paper compares audiograms produced by the conventional nonmasked CAP visual detection threshold technique with audiograms produced by both forward masked derived CAPs and forward masked enhanced CAPs. In response to low and middle frequency stimuli, both masked CAP measures produce more sensitive audiograms than does the conventional nonmasking method. Forward masked amplitude tuning curves (TCs) were also produced, comparing the conventional 50% amplitude reduction and 20 μV amplitude reduction methods with TCs obtained with derived and enhanced CAPs. When the same criteria are used, both masked CAP measures result in sharply tuned amplitude TCs that are approximately 60 dB more sensitive than the conventional CAP technique. At near-threshold levels, the properties of forward masked enhanced and derived CAPs appear to be similar.