Derivatives of Plastics as Potential Carcinogenic Factors: The Current State of Knowledge.

Abstract

Simple SummaryNowadays, micro- and nanoplastic particles can be found almost everywhere, being especially harmful for humans. Their absorption, primarily via inhalation and digestive routes, might lead to a particularly dangerous accumulation of those substances within the human body. Due to the alarming increase in contamination worldwide and excessive production of plastics and synthetic materials, there is an urgent need to investigate the effects of those substances on human health. So far, it has been observed that nano- and microplastics might be extremely harmful, leading to serious health conditions, such as cancers of various human body systems.Micro- and nanoplatics have been already reported to be potential carcinogenic/mutagenic substances that might cause DNA damage, leading to carcinogenesis. Thus, the effects of micro- and nanoplastics exposure on human health are currently being investigated extensively to establish clear relationships between those substances and health consequences. So far, it has been observed that there exists a definite correlation between exposure to micro- and nanoplastic particles and the onset of several cancers. Therefore, we have conducted research using PubMed, Web of Science, and Scopus databases, searching for all the research papers devoted to cancers that could be potentially related to the subject of exposure to nano- and microplastics. Ultimately, in this paper, we have discussed several cancers, including hepatocellular carcinoma, pancreatic cancer, pancreatic ductal adenocarcinoma, biliary tract cancer, and some endocrine-related cancers.