Abstract
In order to obtain new substances with potential biological activity dipeptide derivatives from p-aminobenzoyl-phenylglycine and p-aminobenzoyl-phenylalanine were grafted on 1,2,4-triazolic heterocycle. The new synthesized compounds belong to the group of antimetabolites, group used in medicine for treating malignant tumors. Also, it is possible to study the correlation between chemical structure and biological activity of the new compounds.
Highlights
1.IntroductionThe current trend in chemotherapy of malignant tumours is characterized by using the treatments with the compounds that manifests as antimetabolites
The malignant tumours are considered serious health problems today
The current trend in chemotherapy of malignant tumours is characterized by using the treatments with the compounds that manifests as antimetabolites
Summary
The current trend in chemotherapy of malignant tumours is characterized by using the treatments with the compounds that manifests as antimetabolites. The structure of the new synthesized substances contains the peptide fragment, the indazole ring, and the 1,2,4-triazole heterocycle. In order to obtain derivatives with reduced toxicity and high therapeutic action, a series of syntheses were performed by replacing the hydrogen of the amino group in the molecule of the N-(paminobenzoyl)-D,L-phenylglycine and N-(p-aminobenzoyl)-L-phenylalanine with the 5-mercapto1,2,4-triazole-3,4-disubstituted heterocyclic system. The aim of this research was to establish some physico-chemical properties of the synthesized 1,2,4-triazole-3,4-disubstituted based on aminoacids derivatives having in view their potential biological activity
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