Abstract
Objective: Type 1 diabetes mellitus (DM) results from the autoimmune destruction of pancreatic -cells, loss of insulin secretion and ensuing hyperglycemia. Conventional insulin-therapy maintains normal blood glucose levels, however, this therapy rarely prevents long-term consequences of DM. Cell therapy based upon using intact islets transplanted into patients is an effective treatment for DM, but is limited by a shortage of donor material. ES cells derived from pluripotent cells have potential use in this therapy because they can be propagated indefinitely without differentiation in vitro and they can be directed into any or all cell lineages. However, the safety and efficiency of ES cell-transplantation must be validated in animal models. As the initial step in developing a non-human primate model for ES cell-derived islet transplantation, we investigated the potential of monkey ES cells to differentiate into insulin producing phenotypes in vitro.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
