Abstract
Amisulpride is a substituted benzamide derivative with atypical antipsychotic properties and low side effects. We report four cases of patients with clinically and genetically established Huntington's disease and signs of psychosis who were treated with Amisulpride. Two patients developed extrapyramidal side effects due to the treatment. The antipsychotic therapy of all patients was effective. Due to degeneration of striatal neurons patients suffering from Huntington's disease react early with development of extrapyramidal side effects after therapy with amisulpride.
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