Depyrogenation in key manufacturing processes of Reduning injection

Abstract

To investigate the effect of removing bacterial endotoxin in the key processes of Reduning injection. The content of bacterial endotoxins was detected by kenitic-turbidimetry and the removal efficacy was studied before and after using 0.8% of activated carbon and ultrafiltration with molecular weight cut-off of 10 x 10(3). The adsorption rate of bacterial endotoxins was 78.7% by using activated carbon, while the removal efficacy of bacterial endotoxins was 99.6% with ultrafiltration membrane at cut-off molecular weight 10 x 10(3). The key technology can effectively guarantee the safety of Reduning injection.