Abstract
A polarimetric imaging system capable of continuously selecting imaging depth in a turbid media is demonstrated. The proposed system is based on the orthogonal polarization spectral (OPS) technique, and is able to detect microstructure and microvessel. First, we compare the performance of four polarization imaging channels on a biological phantom, and find that there is a linear relation between the degrees of ellipticity and image contrast in co-linear/co-elliptical channels. In addition, the cross-linear channel has the best image contrast. We then prove the performance of depth selectivity of microvessel in a mouse ear.
Highlights
Microcirculation is the blood circulation between arterioles and venules
A traditional way of imaging microvessel is known as intravital microscopy, a golden standard that allows for accurate detection of capillary and vascular morphology in vivo
Orthogonal polarization spectral (OPS) imaging [5], and its successor Sidestream dark-field (SDF) imaging [6] have become two important mainstream imaging methods based on similar principles
Summary
Microcirculation is the blood circulation between arterioles and venules. Adequate microcirculation is vital for the transport of oxygen and other nutrients, and for the removal of body waste. OPS imaging is widely used to provide a semi-quantitative analysis of the microcirculation of several organs, including the sublingual region, liver, kidney, brain, et al [8,9,10,11,12]. It is relatively portable, inexpensive, and does not require the injection of fluorescence to obtain an excellent level of contrast. Inexpensive, and does not require the injection of fluorescence to obtain an excellent level of contrast It only provides a two-dimensional visualization of the microvasculature, and is limited to detect photons coming from a deep channel [13,14,15]. The cross-section layers between the deep channel and superficial layer can only be detected by mechanically scanning the sample
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