Abstract
Changes in the blood pressure, heart rate, and respiration rate during stimulation of the nerve to the gastrocnemius muscle before and after intravenous injection of noradrenalin were studied in chronic experiments on unanesthetized cats. Stimulation of the nerve to the gastrocnemius muscle in intact animals caused an increase in the blood pressure and the heart and respiration rates. Similar stimulation of the nerve against the background of noradrenalin-induced hypertension led to a fall of blood pressure and quickening of the heart beat. The depressor response was unchanged by β-adrenergic receptor blockade but it disappeared after blockade of muscarinic cholinergic receptors by methylatropine. In unanesthetized decerebrate animals the phase of the fall of blood pressure did not take place. It is suggested that the depressor response of the latter is due to strong cholinergic vasodilatation arising by a reflex mechanism in response to stimulation of the motor nerve in the intact cat.
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