Abstract
ABSTRACT Objective: The aim of the present study was to investigate the depressive symptoms and changes in neurotrophins (BDNF, NGF, NT-3), and cortisol levels in serum of peripheral blood from ostomy patients compared to healthy control group. Methods: We evaluated ostomy (n = 29) and healthy control (n = 30) patients. The neurotrophin (BDNF, NGF, NT-3), and cortisol levels were assessed by ELISA in serum of peripheral blood. Depressive symptoms were defined based on the Hamilton Depression Rating Scale (HDRS), and major depression disorder was based on clinical interviews and was confirmed with the Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I). Results: The results showed a significant decrease in BDNF levels and, a significant increase in NT-3 levels in serum of peripheral blood from ostomy patients when compared to healthy controls. The levels of NGF and cortisol showed no significant differences between groups. The depressive symptom evaluations by HDRS demonstrated a significant increase in ostomy patients when compared to healthy controls. The major depression disorder diagnosis by SCID-I showed no significant difference between groups. Conclusion: Our results suggest ostomy triggers significant depressive symptoms and alterations in neurotrophins levels in serum of peripheral blood samples collected from these patients.
Highlights
Ostomy is a surgically created opening between an internal organ and the body surface, often created as an intestinal[1] or colon[2] surgical part in cases where the body has no natural possibility of releasing intestinal waste
While a urostomy can be formed for a bladder cancer or interstitial cystitis[2], the ileostomy or colostomy is indicated for recovering more sick or operated parts induced by intestinal inflammatory or malignant diseases, such as: colorectal cancer, diverticular disease, intestinal infarction, severe trauma and in complex anal complications[4]
Regarding the depressive symptoms evaluations by Hamilton Depression Rating Scale (HDRS) and the depressive disorder diagnosis by SCID-I, only HDRS had a significant difference between the groups
Summary
Ostomy is a surgically created opening between an internal organ and the body surface, often created as an intestinal[1] or colon[2] surgical part in cases where the body has no natural possibility of releasing intestinal waste. It is necessary to treat complicated abdominal problems or to allow the healing of surgical site[1]. It is possible to see that stoma use significantly reduces the quality of life (QOL), and presenting depressive symptoms after the stoma surgery according to ostomy site[6,8]. The overall prevalence of depression was 24% among rectal cancer survivors with the highest prevalence among those with a previous permanent ostomy (31%)[7]
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