Abstract
Objective: To investigate whether emerging depressive and anxiety symptoms are predictors of seizure recurrence in a cohort of patients with newly diagnosed epilepsy (PWNDE) who did not have a history of psychiatric diagnosis.Methods: A cohort of 283 PWNDE were psychiatrically assessed before antiseizure medication (ASM) therapy and were followed for 12 months to assess seizure recurrence. The influence of depressive and anxiety symptoms score on seizure recurrence was assessed using univariate and multivariate binary logistic regression analysis. Receiver operating characteristic (ROC) curve analysis was utilized.Results: A total of 283 individuals were included in final analysis, and 115 patients (40.6%) experienced seizure recurrence during follow-up. In multivariate logistic regression analysis, NDDI-E and GAD-7 score were associated with an increased risk of seizure recurrence with an adjusted OR of 1.360 (CI: 1.176–1.572; P < 0.001) and 1.101 (CI: 1.004–1.209; P = 0.041), respectively. Additionally, the adjusted OR and 95% CI of seizure recurrence for the “high NDDI-E score and high GAD-7 score” vs. “not high NDDI-E score and not high GAD-7 score” was 7.059 (3.521–14.149) (P for trend < 0.001).Conclusion: We found that an emergence of new psychiatric symptoms including depressive and anxiety symptoms were predictors of seizure recurrence in adults with newly diagnosed epilepsy who did not have psychiatric history.
Highlights
Epilepsy is one of the most common severe brain diseases, affecting more than 70 million subjects worldwide [1]
Multiple prior investigations focused on the useful predictors of seizure recurrence such as imaging [4], EEG [5], and epilepsy-related variables [6] in newly treated patients with epilepsy (PWE)
We included patients with newly diagnosed epilepsy (PWNDE) who completed the depressive and anxiety symptoms assessments before taking ASM treatment, and all participants had a followup period of 12 months after diagnosis
Summary
Epilepsy is one of the most common severe brain diseases, affecting more than 70 million subjects worldwide [1]. About 30–69% patients with newly diagnosed epilepsy (PWNDE) had further seizures even starting appropriate ASM therapy [2, 3]. A cohort study provided evidence that individuals who had lost a child had an increased risk of being diagnosed with epilepsy, indicating the relationship between risk of epilepsy, psychiatric symptoms and stress [7]. Lifetime mood disorder and lifetime generalized anxiety disorder were shown to increase the risk for seizure recurrence in adults with a single unprovoked seizure or newly diagnosed epilepsy [3]. In a cohort of patients with epilepsy (PWE) who received temporal lobe resection to treat epilepsy, a psychiatric lifetime diagnosis was associated with lower seizure-freedom rates and worse surgical outcomes [9]. There may exist more complex cerebral pathologies in PWE with psychiatric history
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
