Abstract
1. 1. Serum of partially hepatectomized rats inhibits, after initial stimulation, the oxygen consumption of Walker ascites carcinoma cells in vitro. A parallel inhibition is seen in lactic acid formation. The effect was observed with serum obtained 18, 30 and 72 hr after surgery. 2. 2. At certain intervals after surgery, catalase activity, is increased in the serum of partially hepatectomized rats. The influence of catalase on oxygen consumption and lactate formation was studied. Although catalase may induce inhibition, the inhibitory effect persists even after inactivation of catalase. Several synergistic factors seem to be involved in the specific action of serum from partially hepatectomized animals.
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