Depression trends in Hepatitis-C PCR positive and PCR negative patients.

Qutabuddin Khuhro,Dr Washdev,Shahkamal Hashmi,Hafeezullah Shaikh

doi:10.12669/pjms.38.1.4788

Qutabuddin Khuhro, Dr Washdev + Show 2 more

Open Access

https://doi.org/10.12669/pjms.38.1.4788

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Abstract

ABSTRACTObjective:To determine the frequency of depression in Hepatitis-C patients and its association clearance of HCVMethods:It is cross sectional study that was conducted between 1st July to 31st December, 2020, at National Institute of Liver and Gastrointestinal Diseases (NILGID),, Dow University of Health Sciences (DUHS).. Both male and female patients aged 18 to 60 years presenting with Hepatitis-C PCR positive or had received DAA for three months and became PCR negative were included in this cross sectional study. Depression was analyzed by Hamilton Depression Rating Scale (HDRS). Mean and standard deviations were calculated and analyzed.Results:Total 210 patients were included in this study, with mean age 36.06 ± 10.11 years. Depression was present in 118 (56.2%) patients. Among patients with HCV PCR positive depression present in 63 (30.0%) patients while in HCV PCR negative 55 (26.0%) patients. Similarly, depression in HCV PCR positive male patients, aged ≤40 years 80 (38.1%) and in HCV PCR negative 56 (26.7%) patients.Conclusion:Patients with chronic Hepatitis-C commonly suffer from depression. However, our study found no significant difference with change in PCR status at 12 weeks.

Highlights

Hepatitis-C is the commonest cause of chronic liver disease is CHC (Chronic Hepatitis-C) in the current era.[1]
This study focused on impact of DAA treatment on depression and Hepatitis-C virus (HCV) clearance in chronic Hepatitis-C population can be associated with changes in trends of depression
A cross sectional study was undertaken at National Institute of Liver and Gastrointestinal Diseases (NILGID), Dow University of Health Sciences (DUHS) for duration of 1st July 2020 till 31st December 2020, having sample size of 210 patients in two groups of 105 patient HCV PCR positive and 105 HCV PCR negative after Institutional Review Board (IRB) approval from DUHS (IRB-1590 dated 27th June, 2020)

Summary

INTRODUCTION

Hepatitis-C is the commonest cause of chronic liver disease is CHC (Chronic Hepatitis-C) in the current era.[1]. HCV has role by direct and indirectly in the occurrence of depression.[2] The mechanism through which HCV effect brain is not fully elucidated yet, it is noted microstructural changes and cerebral metabolite abnormalities results in development of depression.[7] The symptoms of HCV associated depression can be described by. This study focused on impact of DAA treatment on depression and HCV clearance in chronic Hepatitis-C population can be associated with changes in trends of depression. Local data of depression in Hepatitis-C population after advent of DAA in not well documented. This study was designed and conducted in local population presenting in a tertiary care hospital. This can be helpful in determination of current pattern of depression and anticipation management of mood disorder in patients

METHODS

RESULTS

DISCUSSION