Abstract
Studies were reviewed to address the question of whether antidepressant medications were effective in the treatment of panic attacks, and whether this effect was primary or secondary to their effect on depression. Evidence was gathered from studies examining comorbidity of panic and depression, level of depression in panic-disordered patients responsive to antidepressant drugs, and the correlation of initial level of depression to change in panic in patients treated with antidepressants. These lines of evidence converge to demonstrate that there is no support for a link between depressive symptomatology and change in panic symptoms as a consequence of treatment with antidepressant medications.
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