Abstract
MANY of the direct effects of morphine have been attributed to serotonergic mechanisms1 or to the catecholamines2,3. The role of brain monoamines in morphine's capacity as a behavioural reinforcer has only recently been explored4,5, and it has been found that the catecholamine depletor α-methyl-p-tyrosine (AMT) blocks behavioural reinforcement by morphine. Our own wbrk, started before these reports appeared, strongly suggests that dopamine is implicated in this blockade. To study morphine reward we adopted the technique of Beach6 which uses the acquisition and retention of a goal box preference and thereby minimises non-specific effects by experimental drugs on performance.
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