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Abstract
MALARIAL infection depresses the immune response to a variety of antigens in mice1–6 and man7,8. It has been postulated that malarial immunodepression is implicated in the development of a human neoplasm, Burkitt's lymphoma9, the geographical distribution of which coincides with that of holoendemic malaria10. In Swiss mice, malarial infection has been shown to increase the rate of spontaneous lymphomagenesis11; and in adult Balb/c mice to potentiate the induction of lymphomas by the Moloney leukaemia virus, MLV (ref. 12). Here we present evidence that the latter effect is accompanied by a reduction in the detectable levels of circulating neutralizing antibody to MLV, and in particular by the absence of IgG neutralizing antibody.
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