Abstract
The effects of chronic alcohol feeding on biliary glutathione excretion were studied in rats pair fed diets containing either ethanol (36% of total energy) or isocaloric carbodydrate for 4–6 weeks. An exteriorized biliary-duodenal fistula was established and total glutathione (GSH) and oxidized glutathione (GSSG) were measured. A significant decrease was observed in rats fed alcohol chronically compared to their pair fed controls in the biliary excretion of GSH (55.7±37.0 vs 243.1±29.0 μg/ml bile, p<0.025) as well as biliary GSSG (12.5±5.0 vs 49.9±8.0 μg/ml bile, p<0.05) and in bile flow (23.1±1.6 vs 29.2±1.3 μg/min, p<0.05). An acute dose of ethanol tended to exaggerate the decrease on biliary GSH and GSSG in the two groups of animals. The depression in biliary GSH could not be attributed to decreased GSH synthesis since S 35-L-methionine incorporation into hepatic and biliary GSH was unchanged or even increased after chronic ethanol feeding.
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