Abstract
Depression, non-suicidal self-injury (NSSI), and suicidal thoughts and behaviors (STB) often emerge during adolescence. Despite considerable overlap in clinical presentation, risk factors, and implicated neurobiology, there is also evidence for divergence in terms of precursors, correlates, and outcomes. The complex interrelationships amongst these three clinical domains require considering both shared and divergent patterns of risk for depression, NSSI, and STB; a clearer understanding of these developmental trajectories will be needed to guide optimization and tailoring of early interventions.
Highlights
Depression, non-suicidal self-injury (NSSI), and suicidal thoughts and behaviors (STB) often emerge during adolescence
Depression, non-suicidal self-injury (NSSI), and suicidal thoughts and behaviors (STB) are serious clinical problems that frequently emerge during adolescence, a time notable for significant brain development
Genetic risk factors interact with adverse experiences to shape early brain development, especially during critical periods [20], which may set the stage for risk of depression, NSSI and STB [21]
Summary
Depression, non-suicidal self-injury (NSSI), and suicidal thoughts and behaviors (STB) often emerge during adolescence. Depression, non-suicidal self-injury (NSSI), and suicidal thoughts and behaviors (STB) are serious clinical problems that frequently emerge during adolescence, a time notable for significant brain development.
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