Abstract
Background: Among the most ordinary clinical manifestations of Multiple Sclerosis (MS) are depression and the presence of Lower Urinary Tract Symptoms (LUTS). Both can compromise a person’s quality of life. Objective: The objective of this research was to identify the major urinary symptoms and correlate them with quality of life and with depressive symptoms in women with MS. Methodology: This was an observatory, descriptive and correlational study, with non-probabilistic sampling by convenience. This research included women over 18 years old who displayed LUT symptoms and who had been diagnosed with Relapsing-Remitting MS. Assessment consisted of an anamnesis card, the Kurtzke Expanded Disability Status Scale (EDSS), the Incontinence Impact Questionnaire-7 (IIQ-7-BR), the Urogenital Distress Inventory-6 (UDI-6-BR), the Beck Depression Inventory-2 (BDI-II) and the Multiple Sclerosis Quality of Life Questionnaire - Portuguese version (MSQOL-54). Results: 41 women participated in the study, with average age of 50.1 (± 9.45) and average of 4.11 in the EDSS. The most common urinary symptom was urinary urgency (78%). There was no correlation between the severity of the urinary symptom and quality of life. Moderate and significant negative correlation (r = -0.561 p<0.001) was found between depression and the physical component of quality of life and strong negative correlation (r = -0.729 p<0.001) was found between depression and the mental component. Conclusions: The most prevalent urinary symptom was urinary urgency. A strong correlation was found between symptoms of depression and quality of life and there was no correlation between urinary symptoms and quality of life. Keywords: Multiple sclerosis; urinary incontinence; quality of life; depression
Highlights
Among the most ordinary clinical manifestations of Multiple Sclerosis (MS) are depression and the presence of Lower Urinary Tract Symptoms (LUTS)
Multiple Sclerosis (MS) is a chronic, progressive, autoimmune, highly disabling disease[1]. It causes central nervous system (CNS) demyelination, in which the oligodendrocytes and myelin sheath are the main targets of inflammatory processes, causing motor, cognitive, sensory, and urogenital damage, interfering with the autonomy and functioning of patients[1]
On average 200 patients were being treated at the outpatient clinic and according to the consultation schedule, the patients that fit the selection criteria were invited until the sample size was reached
Summary
This was an observatory, descriptive and correlational study, with nonprobabilistic sampling by convenience. Assessment consisted of an anamnesis card, the Kurtzke Expanded Disability Status Scale (EDSS), the Incontinence Impact Questionnaire-7 (IIQ-7-BR), the Urogenital Distress Inventory-6 (UDI-6-BR), the Beck Depression Inventory-2 (BDI-II) and the Multiple Sclerosis Quality of Life Questionnaire - Portuguese version (MSQOL-54). This is an observational study with a descriptive and correlational design. Population and sample Patients undergoing follow-up treatment at the Multiple Sclerosis outpatient clinic of the Hospital de Clínicas of Porto Alegre participated in the study. The inclusion criteria were: women aged 18 years and over, diagnosed with Relapsing-Remitting MS, and with LUTS (such as frequent urination, nocturia, urinary urgency and/or urinary incontinence). Exclusion criteria were: clinical diagnosis of urinary tract infection, pregnancy or puerperal state, comprising a period of up to 6 months
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