Abstract

Background. Patients with the chronic migraine frequently present with memory and attention complaints. However, the prevalence and phenotype of such impairment in chronic migraine have not been studied.Objective – to evaluate the prevalence of the objective cognitive deficit in patients with chronic migraine and factors underlying its etiology. Materials and methods. We recruited 62 subjects with chronic migraine and 36 genderand age-matched controls with low-frequency episodic migraine (not more, then 4 headache days per month) aged 18–59. All patients filled in the Hospital Anxiety and Depression Scale (HADS) and Sheehan Disability Scale. Cognitive function was assessed with the Montreal Cognitive Assessment (MoCA), Digital Symbol Substitution Test (DSST), Rey Auditory Verbal Learning Test (RAVLT), and the Perceived Deficits Questionnaire (PDQ-20).Results. In this study 58 % of patients with chronic migraine complained of memory loss. Cognitive impairment was also found with PDQ-20. Objectively, we found a significant decrease in 90-second DSST results and RAVLT total recall and learning rate. In 40 % of subjects with chronic migraine scored lower than 26 points on MoCA. Patients with chronic migraine more frequently had lower DSST rates as compared to episodic migraine (odds ratio 5.07 (95 % confidence interval – 1.59–16.17); p = 0.003). Depression and anxiety did not correlate with performance on cognitive tests. Chronic migraine (frequent headache) and longer headache history, but not depression, anxiety or medication overuse were independent predictors of cognitive impairment.Conclusion. Subjective and objective cognitive deficits are prevalent in the chronic migraine population. Most often memory and attention are impaired. Longer headache history and presence of chronic migraine are independent risk factors for cognitive impairment in patients with chronic migraine.

Highlights

  • Patients with the chronic migraine frequently present with memory and attention complaints

  • All patients filled in the Hospital Anxiety and Depression Scale (HADS) and Sheehan Disability Scale

  • Cognitive function was assessed with the Montreal Cognitive Assessment (MoCA), Digital Symbol Substitution Test (DSST), Rey Auditory Verbal Learning Test (RAVLT), and the Perceived Deficits Questionnaire (PDQ-20)

Read more

Summary

Оригинальные исследования

Депрессия – не единственная причина когнитивных нарушений у пациентов с хронической мигренью. Жалобы на снижение памяти и внимания у пациентов с хронической мигренью широко распространены в клинической практике. Цель исследования – изучить распространенность и клиническую структуру объективных когнитивных нарушений у пациентов с хронической мигренью, а также факторов, имеющих значение для их развития. Наличие хронической мигрени (частой головной боли) и длительность анамнеза цефалгии (но не депрессия) тревога и злоупотребление анальгетиками являются независимыми факторами риска развития когнитивных нарушений. У пациентов с хронической мигренью отмечена высокая распространенность субъективных и объективных нарушений когнитивных функций, в первую очередь снижения памяти и внимания. Длительный анамнез головной боли и наличие хронической мигрени являются независимыми факторами риска развития когнитивных нарушений у пациентов с хронической мигренью. Sechenov First Moscow State Medical University, Ministry of Health of Russia;

Background
Показатель Indicator
Findings
Тревога Anxiety
Full Text
Published version (Free)

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call