Abstract
Cardiovascular diseases and depression are among the leading causes of death and disability worldwide. An association between depression and an increased risk of suffering from cardiovascular fatal and non-fatal events has been supported by numerous studies [ [1] Hare D.L. Toukhsati S.R. Johansson P. Jaarsma T. Depression and cardiovascular disease: a clinical review. Eur. Heart J. 2014; 35: 1365-1372 Crossref PubMed Scopus (638) Google Scholar ]. This finding suggests that depression could constitute an independent cardiovascular risk factor. However, little is known regarding the position depression holds among more traditional cardiovascular risk factors. This is one of the questions Ladwig et al. try to answer in the paper published in this issue of Atherosclerosis [ [2] Ladwig K.H. Baumert J. Marten-Mittag B. Lukaschek K. Johar H. et al. for the KORA InvestigatorsRoom for depressed and exhausted mood as a risk predictor for all-cause and cardiovascular mortality beyond the contribution of the classical somatic risk factors in men. Atherosclerosis. 2017; 257: 224-231 Abstract Full Text Full Text PDF PubMed Scopus (27) Google Scholar ]. The authors present data on the risk of all-cause, cardiovascular and coronary heart disease mortality in a cohort of 3428 men, from the MONICA/KORA Ausburg surveys [ [2] Ladwig K.H. Baumert J. Marten-Mittag B. Lukaschek K. Johar H. et al. for the KORA InvestigatorsRoom for depressed and exhausted mood as a risk predictor for all-cause and cardiovascular mortality beyond the contribution of the classical somatic risk factors in men. Atherosclerosis. 2017; 257: 224-231 Abstract Full Text Full Text PDF PubMed Scopus (27) Google Scholar ]. Results presented by Ladwig et al. show that depressed and exhausted mood is a robust and independent predictor of the risk to all three mortality endpoints. Moreover, depression and exhausted mood is ranked in an intermediate position between the “big-five” classical cardiovascular risk factors, and it is more strongly associated with mortality than hypercholesterolemia and obesity [ [2] Ladwig K.H. Baumert J. Marten-Mittag B. Lukaschek K. Johar H. et al. for the KORA InvestigatorsRoom for depressed and exhausted mood as a risk predictor for all-cause and cardiovascular mortality beyond the contribution of the classical somatic risk factors in men. Atherosclerosis. 2017; 257: 224-231 Abstract Full Text Full Text PDF PubMed Scopus (27) Google Scholar ]. Room for depressed and exhausted mood as a risk predictor for all-cause and cardiovascular mortality beyond the contribution of the classical somatic risk factors in menAtherosclerosisVol. 257PreviewDepressed mood and exhaustion (DEEX) have gained attention as a risk predictor for cardiovascular disease (CVD). Studies to estimate its ranking in prediction models are sparse. Full-Text PDF
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