Abstract
Responses to low-sodium solution were studied in helical preparations of human umbilical arteries from women with preeclampsia and age-matched normotensive women. Reduction of extracellular sodium concentration (replaced by N-methyl-D-glucamine, NMG) and consequent restoration of extracellular sodium-evoked contractions and relaxations, respectively, in the arteries pretreated with phenoxybenzamine, caffeine, ryanodine, and verapamil. The rate and magnitude of the contraction induced by low-sodium solution and the rate of the relaxation induced by the restoration were less in preeclampsia than in normotension. Therefore, the activity of Na-Ca exchange is depressed in human umbilical arterial smooth muscle in preeclampsia, suggesting a possibility that the depressed activity leads to an abnormal regulation of arterial tone in preeclampsia.
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