Abstract
Human exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) can result in hirsutism and chloracne, symptoms that suggest an alteration in endocrine regulation. Consequently, the effect of TCDD on guinea pig testicular cytochrome P-450 has been investigated. Twelve hours after a single, oral dose of TCDD (1 μg/kg), testicular microsomal cytochrome P-450 content was depressed by approximately 36%. Microsomal cytochrome P-450 content reached a maximal depression at approximately 1 day (52% of control) and remained at this level for 9 days. No appreciable alterations of testicular microsomal heme levels or activity of testicular δ-aminolevulinic acid (ALA) synthetase were observed.
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