Deprenyl is metabolized to methamphetamine and amphetamine in man.

Abstract

British Journal of Clinical PharmacologyVolume 6, Issue 6 p. 542-544 Free Access Deprenyl is metabolized to methamphetamine and amphetamine in man. GP Reynolds, GP ReynoldsSearch for more papers by this authorJD Elsworth, JD ElsworthSearch for more papers by this authorK Blau, K BlauSearch for more papers by this authorM Sandler, M SandlerSearch for more papers by this authorAJ Lees, AJ LeesSearch for more papers by this authorGM Stern, GM SternSearch for more papers by this author GP Reynolds, GP ReynoldsSearch for more papers by this authorJD Elsworth, JD ElsworthSearch for more papers by this authorK Blau, K BlauSearch for more papers by this authorM Sandler, M SandlerSearch for more papers by this authorAJ Lees, AJ LeesSearch for more papers by this authorGM Stern, GM SternSearch for more papers by this author First published: December 1978 https://doi.org/10.1111/j.1365-2125.1978.tb00883.xCitations: 232AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat References Beckett, A.H. & Rowland, M. (1965). Urinary excretion of methylamphetamine in man. Nature, Lond., 206, 1260– 1261. Birkmayer, W., Reiderer, P., Ambrozi, L. & Youdim, M.B.H. (1977). Implications of combined treatment with ‘Madopar’ and L-deprenyl in Parkinson's disease. Lancet, i, 439– 443. Caldwell, J. (1976). The metabolism of amphetamines in mammals. Drug Metab. Revs., 5, 219– 280. Cavanaugh, J.H., Griffith, J.D. & Oates, J.A.(1970). Effect of amphetamine on the pressor response to tyramine: Formation of p-hydroxynorephedrine from amphetamine in man. Clin. Pharmac. Ther., 11, 656– 664. Durden, D.A., Philips, S.R. & Boulton, A.A. (1976). Identification and distribution of benzylamine in tissue extracts isolated from rats pretreated with pargyline. Biochem. Pharmac., 25, 858– 859. Edwards, D.J. & Blau, K. (1973). Phenylethylamines in brain and liver of rats with experimentally induced phenylketonuria-like characteristics. Biochem. J., 132, 95– 100. Elsworth, J.D., Glover, V., Reynolds, G.P., Sandler, M., Lees, A.J., Phuapradit, P., Shaw, K.M., Stern, G.M. & Kumar, P. (1978). Deprenyl administration in man: a selective monoamine oxidase B inhibitor without the ‘cheese effect’. Psychopharmacology, 57, 33– 38. Glover, V., Sandler, M., Owen, F. & Riley, G.J.(1977). Dopamine is a monoamine oxidase B substrate in man. Nature, Lond., 265, 80– 81. Innes, I.R. & Nickerson, M. (1977). Norepinephrine, epinephrine and the sympathomimetic amines. In: The Pharmacological Basis of Therapeutics, ed. L.S. Goodman & A. Gilman pp. 477– 513.New York: Macmillan. Kety, S.S. (1959). Biochemical theories of schizophrenia. Science, 129, 1528– 1532. Knoll, J. (1976). Analysis of the pharmacological effects of selective monoamine oxidase inhibitors. In Monoamine Oxidase and its Inhibition, ed. G.E.W. Wolstenholme & J. Knight pp. 135– 161, Amsterdam: Elsevier. Lees, A.J., Shaw, K.M., Kohout, L.J., Stern, G.M., Elsworth, J.D., Sandler, M. & Youdim, M.B.H. (1977). Deprenyl in Parkinson's disease. Lancet, ii, 791– 796. Magyar, K., Vizi, E.S., Ecsery, Z. & Knoll, J. (1967). Comparative pharmacological analysis of the optical isomers of phenyl-isopropylmethyl-propinylamine (E-250). Acta Physiol. Acad. Sci. Hung., 32, 377– 387. Mendlewicz, J. & Youdim, M.B.H. (1978). The potentiation of the antidepressant properties of 5-hydroxytryptophan by deprenil. J. Neural Transmiss (in press). Parkes, J.D., Tarsy, D., Marsden, C.D., Bovill, K.T., Phipps, J.A., Rose, P. & Asselman, P. (1975). Amphetamines in the treatment of Parkinson's disease. J. Neurol. Neurosurg. Psychiat., 38, 232– 237. Simpson, L.L. (1978). Evidence that deprenyl, a type B monoamine oxidase inhibitor, is an indirectly acting sympathomimetic amine. Biochem. Pharmac., 27, 1591– 1595. Stern, G.M., Lees, A J. & Sandler, M. (1978). Deprenyl in Parkinson's disease. J. Neural Transmiss. in press. Varga, E. & Tringer, L. (1967). Clinical trial of a new type of promptly acting psychoenergetic agent (phenyl-isopropylmethyl-propinylamine-HCl, E-250). Acta Med. Acad. Sci. Hung., 23, 289– 295. Citing Literature Volume6, Issue6December 1978Pages 542-544 ReferencesRelatedInformation