Abstract
It has been shown inin vitro experiments that isolated mitochondria are able to absorb large amounts of calcium in addition to other divalent cations if ATP has been added to the culture medium (Engstrom and De Luca, 1964). This absorption is accompanied by ultrastructural changes in the form of electron dense granules in the matrix of the mitochondria, much larger and more numerous than the granules usually observed in mitochondria (Greenawaltet al, 1964; Peachey, 1964; Reynolds, 1965). In addition, electron microscopic studies have disclosed similar intramitochondrial granules in osteoclasts (Gonzales, 1961), in the epithelium of the renal tubules after administration of parathyroid hormone (Gaulfield, 1964), and in liver cells after poisoning by carbon tetrachloride (Reynolds, 1965). In the latter cells an increased calcium content was also demonstrable in the mitochondrial fraction after ultracentrifugation. The object of the present paper is to describe in neoplastic cells the presence of intramitochondrial granules that are indistinguishable morphologically from those found by the above workers.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
