Abstract
Experimental and clinical investigations have established the relationship between circulating immune complexes and the deposition of immune complexes in glomeruli. In spontaneous disease models, in models induced by antigen administration, and in human glomerulonephritis the principal locations of immune complexes are in the subendothelial, mesangial, and subepithelial areas. The presence of immune complexes in glomeruli can result from local formation, as reviewed in the paper by Dr. Curtis B. Wilson, or from deposition of these substances from circulation. The purpose of this review is to consider the pertinent information on glomerular deposition of circulating immune complexes.
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