Abstract
This project was conducted to obtain metabolic parameters for inhaled 141CeO2 in rats, for related dose effect research. Two hundred and forty three rats were exposed nose-only to polydisperse 141CeO2 aerosols (activity median aerodynamic diameters of 1.0 μm in one group and 0.4 μm in the other), and measurements were made on living and sacrificed animals up to 180 days after inhalation. Immediately after inhalation, about 77% of the initial body burden was in the gastrointestinal (GI) tract, 19% in the lungs, 4% in the nasopharynx (NP) and 0.2% in the trachea (T). Deposits in the NP and T regions were almost completely cleared within 2 days. Retention of 141Ce in the lungs could be represented by the sum of two exponential functions, with effective half-times of 9.9 and 24.3 days. The fractions associated with each were 70% and 30%, respectively. During the first 60 days after inhalation, the amounts of 141Ce in the thoracic lymph nodes increased from 0.003% to 0.022% of the initial body burden, and in the femora from 0.009% to 0.020%. Excretion of 141Ce was mainly via feces.
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