Abstract
It was observed that when very dilute solutions of hydrogen peroxide were employed for the purpose of destroying pyrogens in aqueous dextran solutions, a marked depolymerization of the polysaccharide molecule occurred. Further study demonstrated this effect to occur over a wide range of temperature, pressure, time, and concentration of hydrogen peroxide. It was therefore possible to use hydrogen peroxide in place of the usual hydrolytic agents, such as acids, for the depolymerization of native dextran to smaller molecular weight fragments suitable for use as a blood plasma extender.
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