Abstract

Microspectrofluorometry was used to examine intracellular free calcium changes in single NG108-15 neurons loaded with the Ca 2+ sensitive probe, quin2. The changes in intracellular free Ca 2+ were induced either by depolarizing cells with high K + or veratridine or by the addition of ionomycin. Ca 2+-free medium and various inorganic and organic calcium-channel blocking agents blocked changes in intracellular free Ca 2+ levels, indicating that Ca 2+ entry is most likely through voltage-sensitive calcium channels.

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