Abstract
K +-equilibrium potential was determined in brain cortex slices of rat by measuring 86Rb + distribution between the extra- and intracellular space. The ratio of internal to external Rb + concentration was39±1.8, corresponding to a resting membrane potential of 93.8 mV. Li + (1–126 mM) decreased the membrane potential in both cortex slices and synaptosomes in a concentration-dependent manner. The presence of 1 mM Li + was enough to cause a slight but distinct depolarization. During incubation in Li + -containing medium slices took up K +; however, for depolarization the presence of extracellular Li + seemed to be necessary.
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