Abstract
Classification of tissues is an important problem in biomedicine. An efficient tissue classification protocol allows, for instance, the guided-recognition of structures through treated images or discriminating between healthy and unhealthy regions (e.g., early detection of cancer). In this framework, we study the potential of some polarimetric metrics, the so-called depolarization spaces, for the classification of biological tissues. The analysis is performed using 120 biological ex vivo samples of three different tissues types. Based on these data collection, we provide for the first time a comparison between these depolarization spaces, as well as with most commonly used depolarization metrics, in terms of biological samples discrimination. The results illustrate the way to determine the set of depolarization metrics which optimizes tissue classification efficiencies. In that sense, the results show the interest of the method which is general, and which can be applied to study multiple types of biological samples, including of course human tissues. The latter can be useful for instance, to improve and to boost applications related to optical biopsy.
Highlights
We qualitatively and quantitatively analyze the classification potential of the different depolarization metrics that are calculated from the experimental region of interest (ROI) of the different measured tissues
We show how the classification efficiency depends on the application of different depolarization metric spaces
The qualitative analysis starts by calculating the different depolarization metrics, described in Section 2.1, for every pixel in the corresponding polarimetric images of measured tissues
Summary
Polarimetry appears to be a promising optical technique for biomedical applications because it can. Be combined with other optical techniques, as regular imaging or multispectral imaging, providing a new complementary way of characterization.[10,11,12,13,14,15,16] In past studies, it has been shown for instance that polarimetry allows for the grading of skin diseases,[14,15,16,17]
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